A novel role for MHC class II antigens: evidence implicating a protective effect on tumour cells against cytotoxicity by NK and LAK cells.

Article

A novel role for MHC class II antigens: evidence implicating a protective effect on tumour cells against cytotoxicity by NK and LAK cells.

Immunology - 1 Oct 1994

Lobo P I, Patel H C

Abstract excerpt

There are several lines of evidence clearly demonstrating that major histocompatibility complex (MHC) class I antigens are important in protecting haemopoietic tumour cells from natural killer (NK)-mediated cell lysis. In the present studies we examined the role of MHC class II antigens in afford...

Topics

Antigens, Neoplasm
Cytotoxicity, Immunologic
HLA-D Antigens
Histocompatibility Antigens Class I
Humans
Killer Cells, Lymphokine-Activated
Killer Cells, Natural
Lymphoma, B-Cell
Mutation
Osmotic Fragility
Tumor Cells, Cultured

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