Article
Specificity of HLA class I antigen recognition by human NK clones: evidence for clonal heterogeneity, protection by self and non-self alleles, and influence of the target cell type.
The Journal of experimental medicine - 1 Oct 1993
Litwin V, Gumperz J, Parham P, Phillips J H, Lanier L L
Abstract excerpt
Prior studies using polyclonal populations of natural killer (NK) cells have revealed that expression of certain major histocompatibility complex (MHC) class I molecules on the membrane of normal and transformed hematopoietic target cells can prevent NK cell-mediated cytotoxicity. However, the ex...
Topics
- Adult
- Alleles
- B-Lymphocytes
- Base Sequence
- Cell Line, Transformed
- Clone Cells
- Cytotoxicity, Immunologic
- DNA, Single-Stranded
- Histocompatibility Antigens Class I
- Humans
- Immune Tolerance
- Killer Cells, Natural
- Lymphocyte Subsets
- Molecular Sequence Data