Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Individual NK cell clones lyse both tumor cell targets and herpes simplex virus-infected fibroblasts in the absence of interferon.

Viral immunology - 1 Jan 1990

Canessa A, Chatterjee S, Whitley R J, Prasthofer E F, Grossi C E, Tilden A B

Abstract excerpt

The target specificity of natural killer (NK) cells for either tumor cells or virus-infected cells has been investigated. Lymphocyte clones with the surface phenotype of NK cells (CD3-, CD16+) were obtained by limiting dilution of peripheral blood mononuclear cells stimulated with PHA, Herpes simplex virus type 1 (HSV-1), or Varicella-Zoster antigens. Clones were maintained in media with recombinant interleukin 2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Surface
Share to Cell Line, Transformed

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Clone Cells

Share to Fibroblasts

Share to Interleukin-2

Share to Phenotype

Share to Recombinant Proteins

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 1701642
DOI: 10.1089/vim.1990.3.217

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Individual NK cell clones lyse both tumor cell targets and herpes simplex virus-infected fibroblasts in the absence of interferon.PMID 1701642Read ↗

NK cell-mediated lysis of autologous HCMV-infected skin fibroblasts is highly variable among NK cell clones and polyclonal NK cell lines.Semantic proximity Read ↗

Recognition of virus-infected cells by natural killer cell clones is controlled by polymorphic target cell elements.Semantic proximity Read ↗

Herpesvirus Evasion of Natural Killer CellsSemantic proximity Read ↗

Recognition and destruction of virus-infected cells by human gamma delta CTL.Semantic proximity Read ↗

Human CD8+ herpes simplex virus-specific cytotoxic T-lymphocyte clones recognize diverse virion protein antigensSemantic proximity Read ↗

Specificity of HLA class I antigen recognition by human NK clones: evidence for clonal heterogeneity, protection by self and non-self alleles, and influence of the target cell type.Semantic proximity Read ↗

Infection and inhibition of human cytotoxic T lymphocytes by herpes simplex virus.Semantic proximity Read ↗

Gamma/delta T cell clones and natural killer cell clones mediate distinct patterns of non-major histocompatibility complex-restricted cytolysis.Semantic proximity Read ↗

Stable transduction of the interleukin-2 gene into human natural killer cell lines and their phenotypic and functional characterization in vitro and in vivo.Semantic proximity Read ↗

Human CD8+ CTL recognition and in vitro lysis of herpes simplex virus-infected cells by a non-MHC restricted mechanism.Semantic proximity Read ↗

Role of NKG2D in tumor cell lysis mediated by human NK cells: cooperation with natural cytotoxicity receptors and capability of recognizing tumors of nonepithelial originSemantic proximity Read ↗

Killing of Kaposi's sarcoma-associated herpesvirus-infected fibroblasts during latent infection by activated natural killer cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.