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Article

Fitness of RNA virus decreased by Muller's ratchet.

Nature - 29 Nov 1990

Chao L

Abstract excerpt

Why sex exists remains an unsolved problem in biology. If mutations are on the average deleterious, a high mutation rate can account for the evolution of sex. One form of this mutational hypothesis is Muller's ratchet. If the mutation rate is high, mutation-free individuals become rare and they can be lost by genetic drift in small populations. In asexual populations, as Muller noted, the loss is irreversible and...

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PMID: 2247152
DOI: 10.1038/348454a0

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