Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotype-specific phosphorylation of simian virus 40 tsA mutant large T antigens in tsA N-type and A-type transformants.

Journal of virology - 1 Aug 1991

Knippschild U, Kiefer J, Patschinsky T, Deppert W

Abstract excerpt

To identify molecular differences between simian virus 40 (SV40) tsA58 mutant large tumor antigen (large T) in cells of tsA58 N-type transformants [FR(tsA58)A cells], which revert to the normal phenotype after the cells are shifted to the nonpermissive growth temperature, and mutant large T in tsA58 A-type transformants [FR(tsA58)57 cells], which maintain their transformed phenotype after the temperature shift,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Cell Line, Transformed
Share to Electrophoresis, Polyacrylamide Gel

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Phenotype

Share to Phosphorylation

Share to Precipitin Tests

Share to Temperature

Source

Open in PubMed Open full text

Identifiers

PMID: 1649337
DOI: 10.1128/JVI.65.8.4414-4423.1991
PMCID: PMC248881

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotype-specific phosphorylation of simian virus 40 tsA mutant large T antigens in tsA N-type and A-type transformants.PMID 1649337Read ↗

The cellular chromatin is an important target for SV40 large T antigen in maintaining the transformed phenotype.Semantic proximity Read ↗

Altered phosphorylation at specific sites confers a mutant phenotype to SV40 wild-type large T antigen in a flat revertant of SV40-transformed cells.Semantic proximity Read ↗

SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation.Semantic proximity Read ↗

Thermally inactivated simian virus 40 tsA58 mutant T antigen cannot initiate viral DNA replication in vitro.Semantic proximity Read ↗

Wild-type p53 enhances efficiency of simian virus 40 large-T-antigen-induced cellular transformation.Semantic proximity Read ↗

Mutations in v-Src SH3 and catalytic domains that jointly confer temperature-sensitive transformation with minimal temperature-dependent changes in cellular tyrosine phosphorylation.Semantic proximity Read ↗

Establishment of tsA58 transgenic rats as a source of conditionally immortalized cell lines with differentiated functions.Semantic proximity Read ↗

Stable T-p53 complexes are not required for replication of simian virus 40 in culture or for enhanced phosphorylation of T antigen and p53.Semantic proximity Read ↗

Two conditional tsA mutant simian virus 40 T antigens display marked differences in thermal inactivation.Semantic proximity Read ↗

Temperature-sensitive mutants of Abelson murine leukemia virus deficient in protein tyrosine kinase activity.Semantic proximity Read ↗

Independent expression of the transforming amino-terminal domain of SV40 large I antigen from an alternatively spliced third SV40 early mRNA.Semantic proximity Read ↗

Slow time-dependent cellular transformation induced at restrictive temperature by ts-src mutants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.