A mutation in the catalytic domain of pp60v-src is responsible for the host- and temperature-dependent phenotype of the Rous sarcoma virus mutant tsLA33-1.

doi:10.1016/0042-6822(92)90303-7

Article

A mutation in the catalytic domain of pp60v-src is responsible for the host- and temperature-dependent phenotype of the Rous sarcoma virus mutant tsLA33-1.

Virology - 1 Mar 1992

Foster R, Martin G S

Abstract excerpt

We have analyzed a host- and temperature-dependent mutant of Rous sarcoma virus in order to learn more about the nature of mutations which lead to a host range phenotype. We have cloned and sequenced the v-src genes from this mutant, tsLA33-1, and from its presumed parent, tsLA33. Both the tsLA33...

Topics

Animals
Avian Sarcoma Viruses
Binding Sites
Cell Transformation, Viral
Cells, Cultured
Chick Embryo
Cloning, Molecular
Immunoblotting
Molecular Sequence Data
Mutation
Oncogene Protein pp60(v-src)
Recombinant Fusion Proteins
Temperature

A mutation in the catalytic domain of pp60v-src is responsible for the host- and temperature-dependent phenotype of the Rous sarcoma virus mutant tsLA33-1.

Abstract excerpt

Topics

Discuss the evidence