Article
Characterization of avian retroviruses carrying activated transforming human c-src genes and of steps involved in expression of activated src-PKases in vitro.
Oncogene research - 1 Jan 1990
Tanaka A, Salem M, Eckroade R J, Fujita D J
Abstract excerpt
We have isolated four activated transforming human c-src mutants derived spontaneously from viruses carrying the normal human c-src (SRC) genes in the form of Rous sarcoma virus. These mutants induced transformed cell morphology distinguishable from each other in vitro as well as tumors in chicks...
Topics
- Animals
- Avian Sarcoma Viruses
- Carcinogenicity Tests
- Cell Transformation, Viral
- Cells, Cultured
- Chick Embryo
- Chickens
- Electrophoresis, Polyacrylamide Gel
- Enzyme Activation
- Gene Expression
- Humans
- Mutation
- Oncogene Protein pp60(v-src)
- Phosphorylation
- Precipitin Tests
- Protein-Tyrosine Kinases
- Radioimmunoprecipitation Assay
- Tumor Virus Infections