Article
Mitogenesis by v-Src: fluctuations throughout G1 of classical immediate early AP-1 and mitogen-activated protein kinase responses that parallel the need for the oncoprotein.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Oct 1995
Wyke A W, Frame M C, Gillespie D A, Chudleigh A, Wyke J A
Abstract excerpt
Activation of the tyrosine kinase of a temperature-sensitive mutant v-Src oncoprotein in quiescent Rat-1 cells leads to passage through the cell cycle. Temperature shift experiments show that v-Src is needed to leave G0, to pass a relatively stable G1 "pause" point, and to pass a later G1 point c...
Topics
- Animals
- Avian Sarcoma Viruses
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Line
- Cell Transformation, Neoplastic
- DNA
- Enzyme Activation
- Estradiol
- G1 Phase
- Mitogens
- Mutation
- Oncogene Protein pp60(v-src)
- Protein Serine-Threonine Kinases