Multiple dopamine D4 receptor variants in the human population.

doi:10.1038/358149a0

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Article

Multiple dopamine D4 receptor variants in the human population.

Nature - 9 Jul 1992

Van Tol H H, Wu C M, Guan H C, Ohara K, Bunzow J R, Civelli O, Kennedy J, Seeman P, Niznik H B, Jovanovic V

Abstract excerpt

The dopamine D4 receptor structurally and pharmacologically resembles the dopamine D2 and D3 receptors. Clozapine, an atypical antipsychotic that is relatively free of the adverse effects of drug-induced parkinsonism and tardive dyskinesia, binds to the D4 receptor with an affinity 10 times highe...

Topics

Base Sequence
Binding, Competitive
Cell Line
Clozapine
DNA
DNA Restriction Enzymes
Gene Expression
Genetic Variation
Humans
Introns
Molecular Sequence Data
Pituitary Gland

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Dopamine

Receptors, Dopamine D2

Receptors, Dopamine D4

Repetitive Sequences, Nucleic Acid

Spiperone

Substantia Nigra

Source

Open in PubMed

Identifiers

PMID: 1319557
DOI: 10.1038/358149a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1319557-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Multiple dopamine D4 receptor variants in the human population.PMID 1319557Read ↗

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