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Article

A hypervariable segment in the human dopamine receptor D4 (DRD4) gene.

Human molecular genetics - 1 Jun 1993

Lichter J B, Barr C L, Kennedy J L, Van Tol H H, Kidd K K, Livak K J

Abstract excerpt

The human dopamine D4 receptor contains a novel polymorphism within the putative third cytoplasmic loop of the protein. The polymorphism is characterized by a varying number of direct imperfect 48-bp repeats in the gene. Pharmacological characterization has suggested that this receptor is the site through which the atypical neuroleptic clozapine exerts its antipsychotic action and that some polymorphic variants...

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Source

Identifiers

PMID: 8353495
DOI: 10.1093/hmg/2.6.767

Genes

DRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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A hypervariable segment in the human dopamine receptor D4 (DRD4) gene.PMID 8353495Read ↗

Multiple dopamine D4 receptor variants in the human population.Semantic proximity Read ↗

Dopamine D4 receptor repeat: analysis of different native and mutant forms of the human and rat genes.Semantic proximity Read ↗

The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus.Semantic proximity Read ↗

Association between different psychotic disorders and the DRD4 polymorphism, but no differences in the main ligand binding region of the DRD4 receptor protein compared to controls.Semantic proximity Read ↗

Comparative pharmacological and functional analysis of the human dopamine D4.2 and D4.10 receptor variants.Semantic proximity Read ↗

Dopamine D4 receptor variants in unrelated schizophrenic cases and controls.Semantic proximity Read ↗

Distribution of a novel mutation in the first exon of the human dopamine D4 receptor gene in psychotic patients.Semantic proximity Read ↗

The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus.Semantic proximity Read ↗

A novel hypervariable variable number tandem repeat in the dopamine transporter gene (SLC6A3).Semantic proximity Read ↗

Dopamine D4 receptor gene DRD4 and its association with psychiatric disorders.Semantic proximity Read ↗

Schizophrenia is not associated with DRD4 48-base-pair-repeat length or individual alleles: results of a meta-analysis.Semantic proximity Read ↗

Evidence of positive selection acting at the human dopamine receptor D4 gene locus.Semantic proximity Read ↗

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