Article
Association between different psychotic disorders and the DRD4 polymorphism, but no differences in the main ligand binding region of the DRD4 receptor protein compared to controls.
European journal of medical research - 25 Jun 1996
Weiss J, Mägert H J, Cieslak A, Forssmann W G
Abstract excerpt
The dopamine D4 receptor gene (DRD4 gene) is one of the important candidate genes for schizophrenia and other psychoses. In humans, several alleles with variable repeat numbers of a 48-base-pair element within the third exon are known. The corresponding receptor proteins differ in their pharmacol...
Topics
- Adult
- Alleles
- Binding Sites
- Bipolar Disorder
- DNA
- DNA Primers
- Depressive Disorder
- Female
- Genotype
- Humans
- Ligands
- Male
- Mood Disorders
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Psychotic Disorders
- Receptors, Dopamine D2
- Receptors, Dopamine D4