Article
Dopamine D4 receptor variants in unrelated schizophrenic cases and controls.
American journal of medical genetics - 15 Jul 1993
Sommer S S, Lind T J, Heston L L, Sobell J L
Abstract excerpt
The D4 dopamine receptor (D4DR) exists in multiple allelic forms (Van Tol et al.: Nature 358:149-152, 1992) which involve different numbers of a 48 basepair repeat sequence in the putative third cytoplasmic loop. Different binding properties have been reported for at least three of the alleles in cDNA binding assays with clozapine, an atypical neuroleptic, and spiperone (Van Tol et al., 1992). We have examined...
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