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Functional and pharmacological role of the dopamine D4 receptor and its polymorphic variants

30 Sept 2022

Abstract excerpt

The functional and pharmacological significance of the dopamine D 4 receptor (D 4 R) has remained the least well understood of all the dopamine receptor subtypes. Even more enigmatic has been the role of the very prevalent human DRD4 gene polymorphisms in the region that encodes the third intracellular loop of the receptor. The most common polymorphisms encode a D 4 R with 4 or 7 repeats of a proline-rich...

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PMID: 36267569
DOI: 10.3389/fendo.2022.1014678

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