Article
Efficacy and side-effects of clozapine: testing for association with allelic variation in the dopamine D4 receptor gene.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Nov 1996
Rietschel M, Naber D, Oberländer H, Holzbach R, Fimmers R, Eggermann K, Möller H J, Propping P, Nöthen M M
Abstract excerpt
Genetic factors are supposed to play a major role not only in the etiology of psychiatric disorders but also in individual response to medications. To test the hypothesis that inter-individual differences in response to clozapine and the occurrence of side-effects might be influenced by variations in the dopamine D4 receptor gene, we examined frequencies of four known polymorphic sites affecting protein structure...
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