Article
Efficacy and side-effects of clozapine: testing for association with allelic variation in the dopamine D4 receptor gene.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Nov 1996
Rietschel M, Naber D, Oberländer H, Holzbach R, Fimmers R, Eggermann K, Möller H J, Propping P, Nöthen M M
Abstract excerpt
Genetic factors are supposed to play a major role not only in the etiology of psychiatric disorders but also in individual response to medications. To test the hypothesis that inter-individual differences in response to clozapine and the occurrence of side-effects might be influenced by variation...
Topics
- Adult
- Alleles
- Antipsychotic Agents
- Clozapine
- Female
- Genotype
- Humans
- Male
- Receptors, Dopamine D2
- Receptors, Dopamine D4
- Schizophrenia