Dopamine D4 receptor variants in Chinese sporadic and familial schizophrenics.

doi:10.1002/(sici)1096-8628(19970725)74:4<412::aid-ajmg12>3.0.co;2-l

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Article

Dopamine D4 receptor variants in Chinese sporadic and familial schizophrenics.

American journal of medical genetics - 25 Jul 1997

Hong C J, Lee Y L, Sim C B, Hwu H G

Abstract excerpt

Variation in the number of tandem repeats of a 48 base pair (bp) unit was found in the gene of the dopamine D4 receptor (DRD4). The number of repetitions of the 48bp unit was shown to influence the binding of clozapine, which suggests that different alleles may function differently in vivo and af...

Topics

Adult
Alleles
Antipsychotic Agents
Asian People
China
Clozapine
Disease Susceptibility
Female
Gene Frequency
Genetic Heterogeneity
Humans
Male
Minisatellite Repeats
Protein Binding
Receptors, Dopamine D2
Receptors, Dopamine D4
Schizophrenia
White People

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