Article
Functional characterization of rare variants in human dopamine receptor D4 gene by genotype-phenotype correlations.
Neuroscience - 14 Mar 2014
Michealraj K A, Jatana N, Jafurulla, Narayanan L, Chattopadhyay A, Thelma B K
Abstract excerpt
Next generation sequencing technologies have facilitated a notable shift from common disease common variant hypothesis to common disease rare variant, as also witnessed in recent literature on schizophrenia. Dopamine receptor D4 (DRD4), a G-protein-coupled receptor is associated with psychiatric disorders and has high affinity for atypical antipsychotic clozapine. We investigated the functional role of rare...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.