Article
Functional characterization of rare variants in human dopamine receptor D4 gene by genotype-phenotype correlations.
Neuroscience - 14 Mar 2014
Michealraj K A, Jatana N, Jafurulla, Narayanan L, Chattopadhyay A, Thelma B K
Abstract excerpt
Next generation sequencing technologies have facilitated a notable shift from common disease common variant hypothesis to common disease rare variant, as also witnessed in recent literature on schizophrenia. Dopamine receptor D4 (DRD4), a G-protein-coupled receptor is associated with psychiatric disorders and has high affinity for atypical antipsychotic clozapine. We investigated the functional role of rare...
Topics
- Animals
- Base Sequence
- Blotting, Western
- CHO Cells
- Catalytic Domain
- Cell Membrane
- Cricetinae
- Cricetulus
- Cyclic AMP
- Dopamine
- Extracellular Signal-Regulated MAP Kinases
- Fluorescent Antibody Technique
- Genetic Association Studies