Article
Allelic variation in the D4 dopamine receptor (DRD4) gene does not predict response to clozapine.
Archives of general psychiatry - 1 Nov 1994
Rao P A, Pickar D, Gejman P V, Ram A, Gershon E S, Gelernter J
Abstract excerpt
OBJECTIVE: To test the hypothesis that interindividual differences in response to clozapine therapy might be attributable to the D4 dopamine receptor (DRD4) alleles they carry. Different alleles of the D4 dopamine receptor, coded by the DRD4 gene, differ in the affinity with which they bind the a...
Topics
- Alleles
- Base Sequence
- Clozapine
- Cross-Over Studies
- Double-Blind Method
- Gene Frequency
- Genetic Variation
- Genotype
- Humans
- Molecular Sequence Data
- Placebos
- Probability
- Psychotic Disorders
- Receptors, Dopamine
- Receptors, Dopamine D2
- Receptors, Dopamine D4
- Schizophrenia
- Treatment Outcome