Zinc finger point mutations within the WT1 gene in Wilms tumor patients.

doi:10.1073/pnas.89.11.4791

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Article

Zinc finger point mutations within the WT1 gene in Wilms tumor patients.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1992

Little M H, Prosser J, Condie A, Smith P J, Van Heyningen V, Hastie N D

Abstract excerpt

A proposed Wilms tumor gene, WT1, which encodes a zinc finger protein, has previously been isolated from human chromosome 11p13. Chemical mismatch cleavage analysis was used to identify point mutations in the zinc finger region of this gene in a series of 32 Wilms tumors. Two exonic single base c...

Topics

Amino Acid Sequence
Base Sequence
Exons
Humans
Introns
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides
Polymerase Chain Reaction
Sequence Alignment
Wilms Tumor
Zinc Fingers

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