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Article

Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modifications.

Nucleic acids research - 1 Dec 2016

Hashimoto Hideharu, Zhang Xing, Zheng Yu, Wilson Geoffrey G, Cheng Xiaodong

Abstract excerpt

Mutations in human zinc-finger transcription factor WT1 result in abnormal development of the kidneys and genitalia and an array of pediatric problems including nephropathy, blastoma, gonadal dysgenesis and genital discordance. Several overlapping phenotypes are associated with WT1 mutations, including Wilms tumors, Denys-Drash syndrome (DDS), Frasier syndrome (FS) and WAGR syndrome (Wilms tumor, aniridia,...

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Identifiers

PMID: 27596598
DOI: 10.1093/nar/gkw766
PMCID: PMC5137435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modifications.PMID 27596598Read ↗

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Evidence that WT1 mutations in Denys-Drash syndrome patients may act in a dominant-negative fashion.Semantic proximity Read ↗

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