Article
An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor.
Cell - 29 Jun 1990
Haber D A, Buckler A J, Glaser T, Call K M, Pelletier J, Sohn R L, Douglass E C, Housman D E
Abstract excerpt
We have recently described the isolation of a candidate for the Wilms' tumor susceptibility gene mapping to band p13 of human chromosome 11. This gene, primarily expressed in fetal kidney, appears to encode a DNA binding protein. We now describe a sporadic, unilateral Wilms' tumor in which one allele of this gene contains a 25 bp deletion spanning an exon-intron junction and leading to aberrant mRNA splicing and...
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