Article
An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor.
Cell - 29 Jun 1990
Haber D A, Buckler A J, Glaser T, Call K M, Pelletier J, Sohn R L, Douglass E C, Housman D E
Abstract excerpt
We have recently described the isolation of a candidate for the Wilms' tumor susceptibility gene mapping to band p13 of human chromosome 11. This gene, primarily expressed in fetal kidney, appears to encode a DNA binding protein. We now describe a sporadic, unilateral Wilms' tumor in which one al...
Topics
- Alleles
- Base Sequence
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- DNA, Neoplasm
- DNA-Binding Proteins
- Exons
- Genetic Predisposition to Disease
- Humans
- Introns
- Kidney Neoplasms
- Metalloproteins
- Molecular Sequence Data
- Nucleic Acid Hybridization
- Oligonucleotide Probes
- Polymerase Chain Reaction
- RNA Splicing