Article
The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressor
1 Jul 1993
Abstract excerpt
Alteration of transcription factor function is becoming a common theme in molecular mechanisms of oncogenesis. A recent example of this trend is the isolation and characterization of the chromosome 11p13 Wilms tumor suppressor gene, WT1. The WT1 protein contains a DNA binding domain consisting of four zinc fingers of the Cys 2 ‐His 2 class and a proline‐glutamine rich region capable of regulating transcription....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.