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Article

DNA recognition by splicing variants of the Wilms' tumor suppressor, WT1.

Molecular and cellular biology - 1 Jun 1994

Drummond I A, Rupprecht H D, Rohwer-Nutter P, Lopez-Guisa J M, Madden S L, Rauscher F J, Sukhatme V P

Abstract excerpt

The Wilms' tumor suppressor, WT1, is a zinc finger transcriptional regulator which exists as multiple forms owing to alternative mRNA splicing. The most abundant splicing variants contain a nine-nucleotide insertion encoding lysine, threonine, and serine (KTS) in the H-C link region between the third and fourth WT1 zinc fingers which disrupts binding to a previously defined WT1-EGR1 binding site. We have...

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Identifiers

PMID: 8196623
DOI: 10.1128/mcb.14.6.3800-3809.1994
PMCID: PMC358747

Genes

EGR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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