Article
DNA recognition by splicing variants of the Wilms' tumor suppressor, WT1.
Molecular and cellular biology - 1 Jun 1994
Drummond I A, Rupprecht H D, Rohwer-Nutter P, Lopez-Guisa J M, Madden S L, Rauscher F J, Sukhatme V P
Abstract excerpt
The Wilms' tumor suppressor, WT1, is a zinc finger transcriptional regulator which exists as multiple forms owing to alternative mRNA splicing. The most abundant splicing variants contain a nine-nucleotide insertion encoding lysine, threonine, and serine (KTS) in the H-C link region between the t...
Topics
- Alternative Splicing
- Base Sequence
- Binding Sites
- Cell Line
- DNA
- DNA-Binding Proteins
- Genes, Wilms Tumor
- Genetic Variation
- Genetic Vectors
- Humans
- Insulin-Like Growth Factor II
- Kinetics
- Methylation
- Molecular Sequence Data
- Oligodeoxyribonucleotides
- RNA, Messenger
- Transfection
- Tumor Cells, Cultured