High frequency of somatically acquired p53 mutations in small-cell lung cancer cell lines and tumors.

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Article

High frequency of somatically acquired p53 mutations in small-cell lung cancer cell lines and tumors.

Oncogene - 1 Feb 1992

D'Amico D, Carbone D, Mitsudomi T, Nau M, Fedorko J, Russell E, Johnson B, Buchhagen D, Bodner S, Phelps R

Abstract excerpt

We analysed the p53 open reading frame (ORF) in 16 small-cell lung cancer (SCLC) cell lines by direct sequencing of cDNA/PCR products and in 20 SCLC tumors by chemical cleavage and single-strand conformation polymorphism analyses of genomic DNA/PCR products. Abnormalities of p53 were found in 16/...

Topics

Base Sequence
Carcinoma, Small Cell
Chromosome Mapping
DNA Mutational Analysis
Humans
In Vitro Techniques
Lung Neoplasms
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides
Polymerase Chain Reaction
Tumor Cells, Cultured
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 1312696

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1312696-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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