Article
p53 mutations in human lung tumors.
Cancer research - 1 Apr 1992
Miller C W, Simon K, Aslo A, Kok K, Yokota J, Buys C H, Terada M, Koeffler H P
Abstract excerpt
Mutation of one p53 allele and loss of the normal p53 allele [loss of heterozygosity (LOH)] occur in many tumors including lung cancers. These alterations apparently contribute to development of cancer by interfering with the tumor suppressor activity of p53. We directly sequenced amplified DNA in the mutational hot spots (exons 4-8) of p53 in DNA samples from 40 lung cancers. Most (31 of 40) samples were...
Topics
- Amino Acid Sequence
- Base Sequence
- Carcinoma, Small Cell
- Codon
- Exons
- Genes, p53
- Humans
- Lung Neoplasms
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Tumor Suppressor Protein p53