Article
TP53 mutational pattern in Spanish and Polish non-small cell lung cancer patients: null mutations are associated with poor prognosis.
Oncogene - 11 Dec 1997
de Anta J M, Jassem E, Rosell R, Martínez-Roca M, Jassem J, Martínez-López E, Monzó M, Sánchez-Hernández J J, Moreno I, Sánchez-Céspedes M
Abstract excerpt
Inactivation of TP53 tumor suppressor gene is the most frequent molecular alteration in NSCLC, involving up to 60% of cases. Furthermore, TP53 mutational spectrum is related to the type of mutagen exposure, as well as racial and/or diet differences. Nearly 95% of TP53 perturbations affect codons...
Topics
- Aged
- Amino Acid Substitution
- Carcinoma, Non-Small-Cell Lung
- DNA Mutational Analysis
- Disease-Free Survival
- Female
- Frameshift Mutation
- Gene Deletion
- Gene Frequency
- Genes, p53
- Humans
- Lung Neoplasms
- Male
- Middle Aged
- Mutation