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Article

TP53 mutational pattern in Spanish and Polish non-small cell lung cancer patients: null mutations are associated with poor prognosis.

Oncogene - 11 Dec 1997

de Anta J M, Jassem E, Rosell R, Martínez-Roca M, Jassem J, Martínez-López E, Monzó M, Sánchez-Hernández J J, Moreno I, Sánchez-Céspedes M

Abstract excerpt

Inactivation of TP53 tumor suppressor gene is the most frequent molecular alteration in NSCLC, involving up to 60% of cases. Furthermore, TP53 mutational spectrum is related to the type of mutagen exposure, as well as racial and/or diet differences. Nearly 95% of TP53 perturbations affect codons included within exons 5-8 which encode for almost the entire DNA-binding domain. In this study we addressed the...

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Identifiers

PMID: 9416838
DOI: 10.1038/sj.onc.1201475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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