Use of the single strand conformation polymorphism technique and PCR to detect p53 gene mutations in small cell lung cancer.

Article

Use of the single strand conformation polymorphism technique and PCR to detect p53 gene mutations in small cell lung cancer.

Oncogene - 1 Jun 1991

Hensel C H, Xiang R H, Sakaguchi A Y, Naylor S L

Abstract excerpt

Recent studies have suggested that the p53 oncoprotein might function normally as a tumor suppressor. Mutations in highly conserved regions of the p53 gene have been observed in numerous types of tumors and tumor cell lines. To detect in a more sensitive manner p53 gene mutations in small cell lu...

Topics

Amino Acid Sequence
Base Sequence
Carcinoma, Small Cell
Genes, p53
Humans
Lung Neoplasms
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Polymorphism, Genetic
RNA Splicing

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