Article
Alterations of the p53 gene are common and critical events for the maintenance of malignant phenotypes in small-cell lung carcinoma.
Oncogene - 1 Mar 1992
Sameshima Y, Matsuno Y, Hirohashi S, Shimosato Y, Mizoguchi H, Sugimura T, Terada M, Yokota J
Abstract excerpt
To clarify the incidence, timing and pathogenetic significance of p53 gene alterations in the progression of small-cell lung carcinoma (SCLC), 17 primary tumors, 13 metastases and nine cell lines from 27 patients were analysed by a polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) analysis. Allelic losses and mutations of the p53 gene were detected in 24 out of 25 informative cases...
Topics
- Base Sequence
- Carcinoma, Small Cell
- DNA, Neoplasm
- Genes, p53
- Lung Neoplasms
- Molecular Sequence Data
- Mutation
- Neoplasm Metastasis
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction