Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The p53 gene is very frequently mutated in small-cell lung cancer with a distinct nucleotide substitution pattern.

Oncogene - 1 Oct 1991

Takahashi T, Takahashi T, Suzuki H, Hida T, Sekido Y, Ariyoshi Y, Ueda R

Abstract excerpt

The p53 gene has been implicated as a tumor-suppressor gene whose disruption is involved in the pathogenesis of common human cancers. The results of extensive analysis of p53 mutations in non-small cell lung cancers (NSCLCs) have revealed that p53 is mutated in 45% of NSCLC with base changes different from those of colon cancer. In this study, we examined 17 SCLC tumor samples taken directly from 15 patients as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Codon
Share to DNA Probes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, p53

Share to Lung Neoplasms

Share to Molecular Sequence Data

Share to Mutation

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 1656362

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The p53 gene is very frequently mutated in small-cell lung cancer with a distinct nucleotide substitution pattern.PMID 1656362Read ↗

p53 mutations in non-small cell lung cancer in Japan: association between mutations and smoking.Semantic proximity Read ↗

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group.Semantic proximity Read ↗

High frequency of somatically acquired p53 mutations in small-cell lung cancer cell lines and tumors.Semantic proximity Read ↗

p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features.Semantic proximity Read ↗

TP53 mutations in nonsmall cell lung cancer.Semantic proximity Read ↗

Alterations of the p53 gene are common and critical events for the maintenance of malignant phenotypes in small-cell lung carcinoma.Semantic proximity Read ↗

Aberrations of the p53 tumor suppressor gene in human non-small cell carcinomas of the lung.Semantic proximity Read ↗

Effects of Tp53 Gene Mutations on the Survival of Non-Small Cell Lung Cancer (NSCLC); A Short ReviewSemantic proximity Read ↗

Clinical implication of p53 mutation in lung cancer.Semantic proximity Read ↗

TP53 mutations and lung cancer: not all mutations are created equal.Semantic proximity Read ↗

p53 mutations in primary human lung tumors and their metastases.Semantic proximity Read ↗

A specific spectrum of p53 mutations in lung cancer from smokers: review of mutations compiled in the IARC p53 database.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.