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Article

The p53 gene is very frequently mutated in small-cell lung cancer with a distinct nucleotide substitution pattern.

Oncogene - 1 Oct 1991

Takahashi T, Takahashi T, Suzuki H, Hida T, Sekido Y, Ariyoshi Y, Ueda R

Abstract excerpt

The p53 gene has been implicated as a tumor-suppressor gene whose disruption is involved in the pathogenesis of common human cancers. The results of extensive analysis of p53 mutations in non-small cell lung cancers (NSCLCs) have revealed that p53 is mutated in 45% of NSCLC with base changes different from those of colon cancer. In this study, we examined 17 SCLC tumor samples taken directly from 15 patients as...

Topics

Amino Acid Sequence
Carcinoma, Small Cell
Codon
DNA Probes
Genes, p53
Humans
Lung Neoplasms
Molecular Sequence Data
Mutation
Polymerase Chain Reaction

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PMID: 1656362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1656362-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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