Article
Frequent TP53 gene alterations (mutation, allelic loss, nuclear accumulation) in primary non-small cell lung cancer.
European journal of cancer (Oxford, England : 1990) - 1 Feb 1996
Shipman R, Schraml P, Colombi M, Raefle G, Dalquen P, Ludwig C
Abstract excerpt
Mutations of the TP53 tumour suppressor gene have been reported for many human cancers. A variety of TP53 mutations have also been reported for both primary non-small cell lung cancer (NSCLC) and associated metastases. To assess the pathogenetic significance of TP53 gene alterations in NSCLC, 24 paired samples of primary NSCLC and the corresponding normal lung tissue were analysed for mutations of the TP53 gene...
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