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High frequency of deletion mutations in p53 gene from squamous cell lung cancer patients in Taiwan.

Cancer research - 15 Jan 1998

Wang Y C, Chen C Y, Chen S K, Cherng S H, Ho W L, Lee H

Abstract excerpt

Lung cancer is the leading and second-leading cause of cancer deaths among women and men in Taiwan, respectively. However, the molecular mechanisms involved in lung tumorigenesis in Taiwan remain poorly defined. A study that analyzed the mutation spectrum of the p53 tumor suppressor gene in 35 female lung cancer patients in Hong Kong showed that a high proportion of the mutations observed were deletions,...

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PMID: 9443413

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