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Article

Reversed anion selectivity in cultured cystic fibrosis sweat duct cells.

The American journal of physiology - 1 Jan 1992

Bell C L, Reddy M M, Quinton P M

Abstract excerpt

The human genetic disease cystic fibrosis (CF) is characterized by defective epithelial Cl- conductance (GCl). To distinguish the CF-affected GCl from other Cl- channels, we have studied the properties of GCl in normal and CF cells grown from explanted reabsorptive sweat ducts (RD). The cultured cells from normal subjects retained some of the typical duct cell properties. The Na+ conductance inhibitor amiloride...

Topics

Anions
Cell Division
Cells, Cultured
Chloride Channels
Chlorides
Colforsin
Cyclic AMP
Cystic Fibrosis
Electric Conductivity
Humans
Iodides
Membrane Potentials

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Phenotype

Reference Values

Sweat Glands

Source

Identifiers

PMID: 1310214
DOI: 10.1152/ajpcell.1992.262.1.C32

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1310214-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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