Article
Defective epithelial chloride transport in a gene-targeted mouse model of cystic fibrosis.
Science (New York, N.Y.) - 21 Aug 1992
Clarke L L, Grubb B R, Gabriel S E, Smithies O, Koller B H, Boucher R C
Abstract excerpt
The cystic fibrosis transmembrane conductance regulator (CFTR) gene encodes an adenosine 3',5'-monophosphate (cyclic AMP)-activated chloride channel. In cystic fibrosis (CF) patients, loss of CFTR function because of a genetic mutation results in defective cyclic AMP-mediated chloride secretion a...
Topics
- Amiloride
- Animals
- Biological Transport
- Cells, Cultured
- Chlorides
- Colforsin
- Cyclic AMP
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Disease Models, Animal
- Epithelium
- Intestinal Mucosa
- Membrane Proteins
- Mice
- Mutation
- Nasal Mucosa
- Trachea