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Article

Defective epithelial chloride transport in a gene-targeted mouse model of cystic fibrosis.

Science (New York, N.Y.) - 21 Aug 1992

Clarke L L, Grubb B R, Gabriel S E, Smithies O, Koller B H, Boucher R C

Abstract excerpt

The cystic fibrosis transmembrane conductance regulator (CFTR) gene encodes an adenosine 3',5'-monophosphate (cyclic AMP)-activated chloride channel. In cystic fibrosis (CF) patients, loss of CFTR function because of a genetic mutation results in defective cyclic AMP-mediated chloride secretion across epithelia. Because of their potential role as an animal model for CF, mice with targeted disruption of the murine...

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Source

Identifiers

PMID: 1380724
DOI: 10.1126/science.257.5073.1125

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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