Article
Selective activation of cystic fibrosis transmembrane conductance regulator Cl- and HCO3- conductances.
JOP : Journal of the pancreas - 1 Jul 2001
Reddy M M, Quinton P M
Abstract excerpt
While cystic fibrosis transmembrane conductance regulator (CFTR) is well known to function as a Cl(-) channel, some mutations in the channel protein causing cystic fibrosis (CF) disrupt another vital physiological function, HCO(3)(-) transport. Pathological implications of derailed HCO(3)(-) transport are clearly demonstrated by the pancreatic destruction that accompany certain mutations in CF. Despite the...
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