Article
Control of dynamic CFTR selectivity by glutamate and ATP in epithelial cells.
Nature - 12 Jun 2003
Reddy M M, Quinton P M
Abstract excerpt
Cystic fibrosis is caused by mutations in cystic fibrosis transmembrane conductance regulator (CFTR), an anion channel. Phosphorylation and ATP hydrolysis are generally believed to be indispensable for activating CFTR. Here we report phosphorylation- and ATP-independent activation of CFTR by cytoplasmic glutamate that exclusively elicits Cl-, but not HCO3-, conductance in the human sweat duct. We also report that...
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