Adenosine triphosphate-dependent asymmetry of anion permeation in the cystic fibrosis transmembrane conductance regulator chloride channel.

doi:10.1085/jgp.111.4.601

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Article

Adenosine triphosphate-dependent asymmetry of anion permeation in the cystic fibrosis transmembrane conductance regulator chloride channel.

The Journal of general physiology - 1 Apr 1998

Linsdell P, Hanrahan J W

Abstract excerpt

The cystic fibrosis transmembrane conductance regulator (CFTR) forms a tightly regulated channel that mediates the passive diffusion of Cl- ions. Here we show, using macroscopic current recording from excised membrane patches, that CFTR also shows significant, but highly asymmetrical, permeabilit...

Topics

Adenosine Triphosphate
Animals
Anions
CHO Cells
Cell Line
Chlorides
Cricetinae
Cystic Fibrosis Transmembrane Conductance Regulator
Electric Conductivity
Gluconates
Hydrolysis
Mutation
Permeability

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