Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apical heterotrimeric g-proteins activate CFTR in the native sweat duct.

The Journal of membrane biology - 1 Jan 2001

Reddy M M, Sun D, Quinton P M

Abstract excerpt

Other than the fact that the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel can be activated by cAMP dependent kinase (PKA), little is known about the signal transduction pathways regulating CFTR. Since G-proteins play a principal role in signal transduction regulating several ion channels [4, 5, 9], we sought to test whether G-proteins control CFTR Cl- conductance (CFTR G(Cl)) in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclic AMP
Share to Fluorides
Share to Guanosine 5'-O-(3-Thiotriphosphate)

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Guanosine Diphosphate

Share to Guanosine Triphosphate

Share to Heterotrimeric GTP-Binding Proteins

Share to Sodium Channels

Share to Sodium-Potassium-Exchanging ATPase

Source

Identifiers

PMID: 11155209
DOI: 10.1007/s002320010036

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apical heterotrimeric g-proteins activate CFTR in the native sweat duct.PMID 11155209Read ↗

GTP-binding proteins inhibit cAMP activation of chloride channels in cystic fibrosis airway epithelial cells.Semantic proximity Read ↗

CFTR regulation of intracellular calcium in normal and cystic fibrosis human airway epithelia.Semantic proximity Read ↗

Selective activation of cystic fibrosis transmembrane conductance regulator Cl- and HCO3- conductances.Semantic proximity Read ↗

Activation of cAMP-dependent C1- currents in guinea-pig paneth cells without relevant evidence for CFTR expression.Semantic proximity Read ↗

Activation of the Ae4 (Slc4a9) cation-driven Cl-/HCO3- exchanger by the cAMP-dependent protein kinase in salivary gland acinar cells.Semantic proximity Read ↗

Mouse cystic fibrosis transmembrane conductance regulator forms cAMP-PKA-regulated apical chloride channels in cortical collecting duct.Semantic proximity Read ↗

Adenosine receptors and phosphodiesterase inhibitors stimulate Cl- secretion in Calu-3 cells.Semantic proximity Read ↗

Correction of CFTR malfunction and stimulation of Ca-activated Cl channels restore HCO3- secretion in cystic fibrosis bile ductular cells.Semantic proximity Read ↗

CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells.Semantic proximity Read ↗

Modulation of cystic fibrosis transmembrane conductance regulator (CFTR) activity and genistein binding by cytosolic pH.Semantic proximity Read ↗

Phosphorylation of P-glycoprotein by PKA and PKC modulates swelling-activated Cl- currents.Semantic proximity Read ↗

Phosphate stimulates CFTR Cl- channels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.