Article
CFTR null mutation altered cAMP-sensitive and swelling-activated Cl- currents in primary cultures of mouse nephron.
American journal of physiology. Renal physiology - 1 Apr 2003
Barrière Hervé, Belfodil Radia, Rubera Isabelle, Tauc Michel, Poujeol Chantal, Bidet Michel, Poujeol Philippe
Abstract excerpt
The role of cystic fibrosis transmembrane conductance regulator (CFTR) in the control of Cl(-) currents was studied in mouse kidney. Whole cell clamp was used to analyze Cl(-) currents in primary cultures of proximal and distal convoluted and cortical collecting tubules from wild-type (WT) and cftr knockout (KO) mice. In WT mice, forskolin activated a linear Cl(-) current only in distal convoluted and cortical...
Topics
- Adenosine
- Animals
- Calcium
- Cell Size
- Cells, Cultured
- Chloride Channels
- Chlorides
- Colforsin
- Cyclic AMP
- Cystic Fibrosis Transmembrane Conductance Regulator
- Enzyme Inhibitors