Activity of oxidative routes of metabolism of debrisoquin, mephenytoin, and dapsone is unrelated to the pathogenesis of vinyl chloride-induced disease.

doi:10.1038/clpt.1992.204

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Article

Activity of oxidative routes of metabolism of debrisoquin, mephenytoin, and dapsone is unrelated to the pathogenesis of vinyl chloride-induced disease.

Clinical pharmacology and therapeutics - 1 Dec 1992

Black C, May G, Csuka M E, Lupoli S, Wilkinson G R, Branch R A

Abstract excerpt

The hypothesis, that cytochrome P4502D6, cytochrome P4502CMP, cytochrome P4503A4 or N-acetyl-transferase may form active intermediary metabolites that could be etiologically related to vinyl chloride-induced disease was investigated in 21 drug-free workers with previous development of vinyl chlor...

Topics

Arylamine N-Acetyltransferase
Cytochrome P-450 Enzyme System
Dapsone
Debrisoquin
Humans
Male
Mephenytoin
Middle Aged
Occupational Diseases
Oxidation-Reduction
Phenotype
Regression Analysis
Vinyl Chloride

Source

Open in PubMed

Identifiers

PMID: 1458774
DOI: 10.1038/clpt.1992.204

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1458774-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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