Article
Activity of oxidative routes of metabolism of debrisoquin, mephenytoin, and dapsone is unrelated to the pathogenesis of vinyl chloride-induced disease.
Clinical pharmacology and therapeutics - 1 Dec 1992
Black C, May G, Csuka M E, Lupoli S, Wilkinson G R, Branch R A
Abstract excerpt
The hypothesis, that cytochrome P4502D6, cytochrome P4502CMP, cytochrome P4503A4 or N-acetyl-transferase may form active intermediary metabolites that could be etiologically related to vinyl chloride-induced disease was investigated in 21 drug-free workers with previous development of vinyl chloride-induced disease and in 23 drug-free workers from the same plant who did not develop the syndrome. Each subject...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.