Article
Role of cytochrome P4502D6 in the metabolism of brofaromine. A new selective MAO-A inhibitor.
European journal of clinical pharmacology - 1 Jan 1993
Feifel N, Kucher K, Fuchs L, Jedrychowski M, Schmidt E, Antonin K H, Bieck P R, Gleiter C H
Abstract excerpt
The metabolic fate of brofaromine (CGP 11 305 A), a new, reversible, selective MAO-A inhibitor, has been assessed in poor (PM) and extensive (EM) metabolizers of debrisoquine. Compared to EM, PM had significantly longer t1/2 (136%) and larger AUC(0-infinity) (110%) of the parent compound brofarom...
Topics
- Adult
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System
- Female
- Humans
- Male
- Mixed Function Oxygenases
- Monoamine Oxidase Inhibitors
- Phenotype
- Piperidines