Article
Lung tumor resection does not affect debrisoquine metabolism.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 1994
Shaw G L, Falk R T, Deslauriers J, Nesbitt J C, McKneally M F, Frame J N, Feld R, Issaq H J, Ruckdeschel J C, Hoover R N
Abstract excerpt
Some authors have reported an association of extensive metabolism of debrisoquine with increased lung cancer risk, although others have found no association. Debrisoquine metabolism is controlled by a cytochrome P-450 isozyme encoded at the CYP2D6 locus, which is inducible by antipyrine and rifam...
Topics
- Carcinoma, Non-Small-Cell Lung
- Case-Control Studies
- Debrisoquin
- Female
- Humans
- Lung Neoplasms
- Male
- Metabolic Clearance Rate
- Middle Aged
- Neoplasm Staging
- Phenotype
- Pneumonectomy
- Risk Factors