Article
Lung tumor resection does not affect debrisoquine metabolism.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 1994
Shaw G L, Falk R T, Deslauriers J, Nesbitt J C, McKneally M F, Frame J N, Feld R, Issaq H J, Ruckdeschel J C, Hoover R N
Abstract excerpt
Some authors have reported an association of extensive metabolism of debrisoquine with increased lung cancer risk, although others have found no association. Debrisoquine metabolism is controlled by a cytochrome P-450 isozyme encoded at the CYP2D6 locus, which is inducible by antipyrine and rifampicin. Because lung tumors may produce a variety of humoral substances, we wanted to determine whether the tumor...
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