Article
Mutant genes of cytochrome P-450IID6, glutathione S-transferase class Mu, and arylamine N-acetyltransferase in lung cancer patients.
The Clinical investigator - 1 Jan 2000
Roots I, Brockmöller J, Drakoulis N, Loddenkemper R
Abstract excerpt
Epidemiological studies suggested a protective effect of certain phenotypes of polymorphic foreign-compound-metabolizing enzymes in some types of cancer. Poor metabolizers (PM) of debrisoquine 4-hydroxylase (cytochrome P-450IID6, CYP2D6) were found to be underrepresented among patients with lung...
Topics
- Acetylation
- Aged
- Alleles
- Arylamine N-Acetyltransferase
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- DNA Mutational Analysis
- Female
- Genes
- Genetic Predisposition to Disease
- Genotype
- Glutathione Transferase
- Humans
- Lung Neoplasms
- Male
- Middle Aged
- Mixed Function Oxygenases
- Neoplasm Proteins