Article
Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosome.
Nature genetics - 1 Oct 1992
Smith S A, Easton D F, Evans D G, Ponder B A
Abstract excerpt
A predisposing gene for breast and ovarian cancer has recently been mapped to chromosome 17q12-21. If this gene is a tumour suppressor gene, allele losses would be expected in the tumours of affected family members and the losses should affect the wild-type chromosome, reflecting the need for inactivation of the wild-type allele at the predisposing locus. In four multiple case breast-ovarian cancer families, we...
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