Article
Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosome.
Nature genetics - 1 Oct 1992
Smith S A, Easton D F, Evans D G, Ponder B A
Abstract excerpt
A predisposing gene for breast and ovarian cancer has recently been mapped to chromosome 17q12-21. If this gene is a tumour suppressor gene, allele losses would be expected in the tumours of affected family members and the losses should affect the wild-type chromosome, reflecting the need for ina...
Topics
- Alleles
- Breast Neoplasms
- Chromosome Mapping
- Chromosomes, Human, Pair 17
- Female
- Gene Deletion
- Genes, Tumor Suppressor
- Humans
- Male
- Ovarian Neoplasms
- Pedigree