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Article

A deletion unit on chromosome 17q in epithelial ovarian tumors distal to the familial breast/ovarian cancer locus.

Cancer research - 15 Mar 1993

Jacobs I J, Smith S A, Wiseman R W, Futreal P A, Harrington T, Osborne R J, Leech V, Molyneux A, Berchuck A, Ponder B A

Abstract excerpt

Linkage analysis in familial breast and ovarian cancer and studies of allelic deletion in sporadic ovarian tumors have suggested that chromosome 17q may be the location of a gene of importance in ovarian carcinogenesis. We have examined tumor and normal DNA samples from 120 patients with ovarian tumors for allelic deletion at 12 loci on chromosome 17q. Allelic deletion was observed in 64 cases (53%) of which 56...

Topics

Alleles
Base Sequence
Blotting, Southern
Breast Neoplasms
Chromosome Mapping
Chromosomes, Human, Pair 17
Female
Gene Deletion
Genes, Tumor Suppressor
Genetic Linkage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Molecular Sequence Data

Ovarian Neoplasms

Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 8095178

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8095178-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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