Article
A prospective study of hprt mutant and mutation frequencies in treated cancer patients.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2000
Caggana M, Liber H L, Coleman C N, Mauch P, Clark J R, Kelsey K T
Abstract excerpt
We previously reported that some Hodgkin's disease patients had elevated hprt mutant frequencies in peripheral blood lymphocytes long after cessation of therapy. To determine if these elevations in mutant frequency represent true persistently elevated mutation frequencies, we recruited for a prospective study six previously treated Hodgkin's disease patients and five patients who had been treated for squamous...
Topics
- Adult
- Aged
- Antineoplastic Agents
- Carcinoma, Squamous Cell
- Head and Neck Neoplasms
- Hodgkin Disease
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Middle Aged
- Mutation