Molecular bases of hprt mutations in malathion-treated human T-lymphocytes.

doi:10.1016/s0027-5107(97)00200-5

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Article

Molecular bases of hprt mutations in malathion-treated human T-lymphocytes.

Mutation research - 2 Feb 1998

Pluth J M, O'Neill J P, Nicklas J A, Albertini R J

Abstract excerpt

Recently, we reported that 6 of 84 (7.1%) hprt mutants arising in in vitro malathion-treated human T-lymphocytes were characterized by specific genomic deletions in a 125-bp region of exon 3 (Pluth et al., Cancer Research 56 (1996) 2393-2399. We have now extended study to determine whether additi...

Topics

Humans
Hypoxanthine Phosphoribosyltransferase
Insecticides
Malathion
Male
Mutation
Polymerase Chain Reaction
RNA Splicing
Sequence Deletion
T-Lymphocytes

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