In vivo somatic mutation in the lymphocytes of Hodgkin's disease patients.

doi:10.1002/em.2850180103

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Article

In vivo somatic mutation in the lymphocytes of Hodgkin's disease patients.

Environmental and molecular mutagenesis - 1 Jan 1991

Caggana M, Liber H L, Mauch P M, Coleman C N, Kelsey K T

Abstract excerpt

While current medical therapies for Hodgkin's disease are usually quite effective, it has become increasingly clear that some of the therapies utilized carry an inherent risk for the induction of secondary malignancies. In order to examine the cellular and genetic responses to therapy for Hodgkin's disease among individuals, we have determined the mutant frequency of T-lymphocytes in 3 cohorts of patients (N =...

Topics

Adult
Aged
Aged, 80 and over
Analysis of Variance
Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cells, Cultured
Clone Cells
Cohort Studies
Combined Modality Therapy
Dacarbazine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Doxorubicin

Follow-Up Studies

Hodgkin Disease

Humans

Hypoxanthine Phosphoribosyltransferase

Lymphocytes

Mechlorethamine

Source

Open in PubMed

Identifiers

PMID: 1713845
DOI: 10.1002/em.2850180103

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1713845-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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