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p53 mutations and MDM-2 amplification in renal cell cancers.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Sept 1994

Imai Y, Strohmeyer T G, Fleischhacker M, Slamon D J, Koeffler H P

Abstract excerpt

Genomic DNA from 53 primary human renal cell tumors was screened for the presence of mutations in the tumor suppressor gene p53, using the polymerase chain reaction and single-strand conformation polymorphism analysis, followed by direct sequencing of DNA. Five cases showed mobility shifts. Sequencing of these samples revealed two cases of nonsense mutations (codons 182, 192), one case of a missense mutation...

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PMID: 7824511

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