p53 mutations and MDM-2 amplification in renal cell cancers.

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Article

p53 mutations and MDM-2 amplification in renal cell cancers.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Sept 1994

Imai Y, Strohmeyer T G, Fleischhacker M, Slamon D J, Koeffler H P

Abstract excerpt

Genomic DNA from 53 primary human renal cell tumors was screened for the presence of mutations in the tumor suppressor gene p53, using the polymerase chain reaction and single-strand conformation polymorphism analysis, followed by direct sequencing of DNA. Five cases showed mobility shifts. Seque...

Topics

Base Sequence
Blotting, Southern
Carcinoma, Renal Cell
DNA Primers
DNA, Neoplasm
Gene Amplification
Genes, p53
Humans
Kidney Neoplasms
Molecular Sequence Data
Mutation
Neoplasm Proteins
Nuclear Proteins
Polymerase Chain Reaction
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-mdm2

Source

Open in PubMed

Identifiers

PMID: 7824511

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7824511-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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