Retinoblastoma gene mutation in primary human renal cell carcinoma.

Article

Retinoblastoma gene mutation in primary human renal cell carcinoma.

Oncology research - 1 Jan 1995

Shuin T, Torigoe S, Kubota Y, Kishida T, Hosaka M, Horikoshi T, Yao M, Kondo K, Sakai N, Danenberg K

Abstract excerpt

We searched for possible mutations in the E2F-binding region of retinoblastoma gene in primary human renal cell carcinomas, using polymerase chain reaction and single-strand conformational polymorphism analysis of RNA. Retinoblastoma gene mutation was detected in 1 of 21 cases (5%). DNA sequencin...

Topics

Base Sequence
Binding Sites
Carcinoma, Renal Cell
Exons
Genes, Retinoblastoma
Humans
Kidney Neoplasms
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational

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