Article
Assessment of the frequency of mutant (hprt-) T lymphocytes from peripheral blood of patients with Hashimoto's thyroiditis.
Thyroid : official journal of the American Thyroid Association - 1 Jul 2003
Liakata E, Philippou G, Souvatzoglou A, Lymberi P, Carayanniotis G
Abstract excerpt
A salient feature of Hashimoto's thyroiditis (HT) is the T-cell-mediated destruction of the thyroid gland leading to hypothyroidism. In HT, as in other autoimmune diseases, a central premise has been that autoreactive T cells must be dividing in response to autoantigens, accumulating random spontaneous mutations during the activation process. Here, we have examined this hypothesis by using as monitor of somatic...
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