Article
Class II HLA-DR antigens on non-autoimmune human thyroid cells stimulate autologous T cells with high suppressor activity.
Autoimmunity - 1 Jan 1990
Lahat N, Sheinfeld M, Sobel E, Baron E, Kraiem Z
Abstract excerpt
Human autoimmune thyroid cells "spontaneously" express MHC-class II antigens. These antigens have been assumed to trigger thyroid-specific helper T cell clones, leading in turn to the expansion of thyroid autoantibody-secreting B cells. Thyroid cells derived from non-autoimmune subjects do not ex...
Topics
- Antigen-Presenting Cells
- Cell Division
- Cells, Cultured
- HLA-DR Antigens
- Histocompatibility Antigens Class I
- Humans
- Interferon-gamma
- Interleukin-2
- Lymphocyte Activation
- Phenotype
- T-Lymphocytes, Cytotoxic
- T-Lymphocytes, Helper-Inducer
- T-Lymphocytes, Regulatory
- Thyroid Gland